Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1981 | 1981-30603 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54M, I84V, L90M | L10F, G73T | I15V, G16A, L19I, K20I, E34Q, M36I, R41K, G51A, L63P, A71I, I72V, P79AD, I85V, I93L |
| >1981-30603| codons 4-99 TLWQRPFVTIKVAGQIIEALLDTGADDTVLQEINLPGKWKPKMIGGIAGFMKVRQYDQIP IEICGHKIVTTVLVGDTPVNVVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219E | Y181C | T39TA, D86N, V118I, K122E, K173R, G196E, T200A, Q207E, F214L, V245K |
| >1981-30603| codons 38-247 CAEMEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLVDFRELNKRTQNFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRRQNPDIVICQYVDDLYVGSDLEIEQHRAKIEELREHLLRWGLFTP DEKHQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |