Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1980 | 1980-30515 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V, L90M | L10F, G73T, L89V | I13V, I15V, K20T, E34K, G51A, L63P, I64V, A71V, V77I, I93L |
| >1980-30515| codons 4-99 TLWQRPFVTVKVGGQLTEALLDTGADDTVLKEMNLPGRWKPKIIGGIAGFMKVRQYDQIP VEICGHKVITTVLIGPTPVNVIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | Y181C, G190S | K101H | K43X, E44D, V118I, K122E, S162C, F171Y, D177E, I178L, E203EK, H208Y, R211K, K223E, L228H |
| >1980-30515| codons 38-247 CTELEXDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPYRKQNPELVICQYMDDLYVSSDLEIGQHRTKIKELRQYLWKWGFYTP DNKHQEEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |