Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1931 | 1931-30508 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, F53L | L10V, I15V, K20R, E35D, M36I, N37E, K55R, I62V, L63P, T74S, L89M |
| >1931-30508| codons 4-99 TLWQRPVVTIKVGGQLREALIDTGADDTVLEDIELPGRWKPKLIGGIGGLVRVRQYDQVP IEICGHKAIGSVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T215Y | V60VI, K102R, V111VI, K122E, D123N, I135V, Q174QR, H208HY |
| >1931-30508| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKRKKSVTVLDIGDAYFSVPLDENFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQYLLRWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |