Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1084 | 1084-30430 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K103N, Y181C, G190A | A98G, V179F | T39TA, K43N, E44D, V118VI, K122E, I142T, E169D, H208Y, R211RK, L228H, V245T |
| >1084-30430| codons 38-247 CAELENDGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSP AIFQSSMTKILDPFRKQNPDIFICQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | V11VI, G73T | L10I, K20I, L63P, I64V, A71V, I72L, P79A |
| >1084-30430| codons 4-99 TLWQRPIITIKIGGQLIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYDQIP VEICGHKVLTTVLVGATPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |