<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1083 1083-30429 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219N K101E, Y181C, G190A V108I, K238N T39A, K43E, E44A, K49KR, K64R, V90VI, V118I, S162D, I195IK, T200A, E203K, Q207E, R211K, K223E  
>1083-30429| codons 38-247
CAELEEAGKISRIGPENPYNTPVFAIRKKNSTKWRKVVDFRELNKRTQDFWEIQLGIPHP
AGLEKKKSVTILDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQDSMTKILEPFRKQNPDIVICQYVDDLYVASDLEKGQHRAKIKELREHLWKWGFYTP
DNKHQEEPPFLWMGYELHPDNWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82T, L90M L10F, L23I, L33F, K43T, F53L K20R, E35D, M36I, K55R, I62V, L63P, A71V, I93L  
>1083-30429| codons 5-99
LWQRPFVTIKIGGQLREAILDTGADDTVFEDINLPGRWTPKLIGGIGGLVRVRQYDQVPI
EICGHKVIGTVLVGPTPTNIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006