Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1083 | 1083-30429 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K101E, Y181C, G190A | V108I, K238N | T39A, K43E, E44A, K49KR, K64R, V90VI, V118I, S162D, I195IK, T200A, E203K, Q207E, R211K, K223E |
| >1083-30429| codons 38-247 CAELEEAGKISRIGPENPYNTPVFAIRKKNSTKWRKVVDFRELNKRTQDFWEIQLGIPHP AGLEKKKSVTILDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPDIVICQYVDDLYVASDLEKGQHRAKIKELREHLWKWGFYTP DNKHQEEPPFLWMGYELHPDNWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82T, L90M | L10F, L23I, L33F, K43T, F53L | K20R, E35D, M36I, K55R, I62V, L63P, A71V, I93L |
| >1083-30429| codons 5-99 LWQRPFVTIKIGGQLREAILDTGADDTVFEDINLPGRWTPKLIGGIGGLVRVRQYDQVPI EICGHKVIGTVLVGPTPTNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |