Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1081 | 1081-30417 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V | N83D | L10I, I13V, G16A, K20R, A22V, E35D, M36I, I62V, L63P, A71T |
| >1081-30417| codons 4-99 TLWQRPIVTVKIAGQLREVLLDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYDQVP IEICGHKTIGTVLVGPTPVDVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, Y115F, M184V | V75I | K122E, D177DE, I178IM, V179VI, R211K |
| >1081-30417| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTRWRKLIDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAFFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEMIIYQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |