Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1080 | 1080-30414 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219R | K103N, Y181C, G190A | A98G | E44D, V118I, K122E, D123E, K173R, Q174E, G196GE, I202V, E203K, H208Y, R211K, H221Y, V245E |
| >1080-30414| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRRENPDIVICQYMDDLYVASDLEIEQHRTKVKELRQYLWKWGFYTP DRKYQKEPPFLWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46LV, L76V, I84V | V11VI, L89V | L10R, T12P, I13V, L19M, K20I, E34EQ, E35D, M36I, K55R, R57K, D60E, I62V, L63P, A71I, T91A, I93L |
| >1080-30414| codons 4-99 TLWQRPRIPVKIGGQMIEALLDTGADDTVLQDINLPGRWKPKVIGGIGGFIRVKQYEQVP IEICGHKIIGTVVVGPTPVNVIGRNVLAQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |