Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1079 | 1079-30408 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I84V, L90M | L33F | L10I, I13V, K14KR, N37ND, L63P, A71V, I72ILM, V77I, Q92K, I93L | G73N |
| >1079-30408| codons 4-99 TLWQRPIVTVRIGGQLKEALLDTGADDTIFEEMDLPGRWKPKIVGGIGGFIKVRQYDQIP IEICGHKVMNTVLIGPTPVNVIGRNLMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219N | K101E, Y181C, G190A | V108I | K43E, E44A, W88C, V118I, K122E, D123DN, Q174K, I178L, I195IT, G196GE, T200TA, E203K, Q207E, H208Y, R211K, H221Y |
| >1079-30408| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKLMDFRELNKRTQDFCEVQLGIPHP AGLEKKKSVTILDVGDAYFSIPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKNPDLVICQYVDDLYVASDLETEQHRAKIKELREYLWKWGFYTP DNKYQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |