Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2439 | 2439-30819 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | Q58E | L10V, I15V, K20R, E35D, M36I, R41K, I62V, L63P, I93L |
| >2439-30819| codons 4-99 TLWQRPVVTIKVGGQLREALLDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVREYDQVP IEICGHKAIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, T215F | K103N | R83K, K102KR, K122P, D123E, D177E, Q207E |
| >2439-30819| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHP AGLKRNKSVTVLDVGDAYFSVPLDPEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGFFTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |