Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2317 | 2317-30813 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MI, I54V, V82A, I84IV, L90M | L10I, I15V, K20R, M36I, L63P, A71V |
| >2317-30813| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTILEEINLPGRWKPKIIGGIGGFVKVRQYDQIP IEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69DY, L210W, T215Y | K103N, Y181FI | T39A, E44D, R83K, A98S, V118VI, K122E, D123E, D177E, E203EK, Q207E, R211K, H221HY, L228H, V245E |
| >2317-30813| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSYKWRKLVDFRELNKKTQDFWEVQLGIPHP SGLKKNKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIIQYMDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTP DKKYQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |