Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2315 | 2315-30806 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | V11I, L33F, F53L, G73S | T4S, L10V, I13V, I15V, L19LI, E34Q, M36L, L38W, K55KR, I62V, L63P, A71V |
| >2315-30806| codons 4-99 SLWQRPVITVKVGGQIKEALLDTGADDTVFQELNWPGRWKPKMIGGIGGLVRVRQYDQVP IEICGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L210W, T215Y | K219E | K103N, Y181C | K101H | S68G, L109LI, D123E, S162C, K173KQ, R211K, D218E, Q242K |
| >2315-30806| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNGTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLHKNKSVTVIDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRQQNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTP EEKHQKEPPFLWMGYELHPDKWTVKPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |