Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2291 | 2291-30819 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219R | A98G | T39A, K43E, R83K, I142V, G196E, H208F, R211K, D218E, V245E |
| >2291-30819| codons 38-247 CAELEEEGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTKIEELRQFLWKWGFYTP ERKHQKEPPFLWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76LV, I84V, L90M | L33F, G73GC, L89AV | L10I, I13V, N37D, R57K, L63P, I66V, A71V, V77I | K20AITV |
| >2291-30819| codons 4-99 TLWQRPIVTVKIGGQLVEALLDTGADDTVFEEMDLPGRWKPKIIGGIGGFMKVKQYDQIP IEVCGHKVICTVVIGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |