Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2092 | 2092-30724 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, Y115F, Q151M | A62V, K70S, V75I, F77L, F116Y, T215I, K219Q | K101E, G190S | Y188YF | T58N, D123E, I135M, I167V, V179VI, T200I, R211K |
| >2092-30724| codons 38-247 CTEMEKEGKISKIGPENPYNNPVFVIKKKNSTSWRKLIDLRELNKRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAFYSVPLDKEFRKYTAFTIPSMNNETPGIRYQYNVLPMGWKGSP AIFQSSMTKVLEPFRKQNPDIIIYQYMDDLFVSSDLEIGQHRIKIEELRQHLLKWGFITP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54V, V82C, I84V, L90M | L10F, L33F, N88D | T12S, I13V, K45R, Q61QH, I62V, L63P, I66V, A71T, I72T, P79X, Q92R, I93L, C95F |
| >2092-30724| codons 4-99 TLWQRPFVSVKIGGQLKEALLDTGADNTVFEEMNLPGRWKPRMIGGIGGFVKVRQYDHVP IEVCGHKTTGTVLVGXTPCNVIGRDLMTRLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |