Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2091 | 2091-30711 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54A, V82A | L24I, L33F, K43T, N83D | L10I, I13V, K20KR, M36L, N37D, Q61QHKN, I62V, L63Q, I64V, I72IV, T74AS |
| >2091-30711| codons 4-99 TLWQRPIVTVKIGGQLREALIDTGADDTVFEELDLPGRWTPKLIGGIGGFAKVRQYDNVQ VEICGHKAVGSVLVGPTPADIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184I, L210W, T215Y | K219N | L100I, K103N | T39A, E40F, V90VI, V118I, K122E, V179I, T200A, E203K, Q207E, H208HY, R211K, K223E, L228H |
| >2091-30711| codons 38-247 CAFLEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEIQLGIPHP AGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYIDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTP DNKHQEEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |