Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2089 | 2089-30630 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, M184V, L210W, T215Y | G190A | V108VI | K43E, E44A, A98S, K122E, I142V, T200A, E203K, Q207D, H208Y, R211K, K223Q, L228H |
| >2089-30630| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGIPHP SGLKKKKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVASDLEIGQHRAKIKELRDYLWKWGFYTP DKKHQQEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | G73S | L10I, K20R, E35D, M36I, N37D, R41K, D60E, I62V, L63P, A71V, I93L |
| >2089-30630| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGKWKPKMIGGIGGFVKVRQYEQVP IEICGHKVISTVLVGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |