Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1973 | 1973-30619 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I54V, V82T, I84V | V11VI, L33F, K43T, M46V, F53L | L10I, I13IV, I15V, K20R, E35D, M36V, N37NS, R41RK, L63P, I66F, A71V | T80TS |
| >1973-30619| codons 4-99 TLWQRPIITVKVGGQLREALLDTGADDTIFEDVSLPGKWTPKVIGGIGGLVKVRQYDQIP IEFCGHKVIGTVLVGPSPTNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L210W, T215Y | T39TA, K43E, V118I, K122KE, I135L, Q174QK, T200TI, E203ED, Q207E, H208HY, R211K, L228H |
| >1973-30619| codons 38-247 CAELEEEGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKNPDIVIYQYMDDLYVGSDLEIGQHRIKIDELREYLWKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |