Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1972 | 1972-30618 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L10F, L24I, L33F, Q58E | T12Q, K55R, R57K, I62V, L63P, I64V, H69K, V77I |
| >1972-30618| codons 4-99 TLWQRPFVQIKIGGQLKEALIDTGADDTVFEEMNLPGRWKPKIIGGIGGFVRVKEYDQVP VEICGKKAIGTVLIGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, V75T, M184V, T215F | K219E | L100I, K103N | V60I, T69N, V90I, I135L, S162A, V179VI, G196E, L228H | A98*S |
| >1972-30618| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSNRWRKITDFRELNKRTQDFWEIQLGIPHP SGIKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFRKQNPDIIIYQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTP DEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |