Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1742 | 1742-30522 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IV, I84V, L90M | L10I, I15V, K20MR, E35D, M36I, N37D, R41RK, D60E, I62V, L63AP, A71T, I72IT, I85IV, Q92QK |
| >1742-30522| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTVLEDIDLPGKWKPKMIGGIGGFVKVRQYEQVP IEICGHKTTGTVLVGPTPVNVVGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, Y115F, Q151M, M184MIV | A62V, V75I, F77L, F116Y, K219Q | K101KPQT, G190GA | T69N, K122KE, F214FL, D218E |
| >1742-30522| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKNSNKWRKLIDLRELNKRTQDFWEVQLGIPHP AGLTKKKSVTVLDVGDAFYSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVASDLEIGQHRTKIEELRQHLLRWGLTTP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |