Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1739 | 1739-30417 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I50V, I54V, V82A, L90M | V11I, L33F, K43T, F53L, L89V | L10IV, I13V, K20R, E35D, M36I, R41K, K55R, D60E, I62V, L63P, I64M, A71I, Q92R, I93L, C95F |
| >1739-30417| codons 4-99 TLWQRPVITVKIGGQLREALLDTGADDTVFEDINLPGKWTPKLIGGVGGLVRVRQYEQVP MEICGHKIIGTVLVGPTPANIIGRNVMTRLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115F, Q151M, L210W | A62V, V75I, F77L, F116Y | K101E, Y181C, G190A | V179F | T58N, S68G, T69I, K102Q, K103R, K122E, S162C, R172K, Q174K, R211AT |
| >1739-30417| codons 38-247 CTEMEKEGKISKIGPENPYNNPVFVIKRKDGIKWRKLIDLRELNKRTQDFWEVQLGIPHP AGLEQRKSVTVLDVGDAFYSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQCSMTKILEPFKKKNPDIFICQYMDDLYVASDLEIGQHRTKIEELRQHLWTWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |