Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1078 | 1078-30409 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I54V, V82A, L90M | L33F, T74P | L10I, I13V, G16A, K20R, L24F, M36I, K55R, I62V, L63P, I66V, G73V, I85L |
| >1078-30409| codons 4-99 TLWQRPIVTVKIAGQLREALFDTGADDTIFEEINLPGRWKPKLIGGIGGFVRVRQYDQVP IEVCGHKAIVPVLVGPTPANILGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K101E, Y181C, G190A | V108I | T39A, E44D, K64H, V118I, K122E, I135IT, V179VI, T200K, Q207KN, H208HY, R211HN, K223Q |
| >1078-30409| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIHKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYVDDLYVASDLEIGQHRKKIEELRNYLWNWGFYTP DNKHQQEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |