<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1077 1077-30404 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54A, V82A, I84V L24I L10I, D60E, Q61DN, I62V, L63P, A71V, I72V, V77I  
>1077-30404| codons 4-99
TLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFAKVRQYENVP
IEICGHKVVGTVLIGPTPANVIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74LI, V75VAIT, M184V, L210W, T215Y K219N L100LI, K103KN A98G E44D, S105T, T107TS, V118I, D123E, I135T, S162D, D177E, G196E, T200TA, I202IV, E203K, R211K, K223E, L228H  
>1077-30404| codons 38-247
CTELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHP
GGIKKNKTVSVLDVGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQDSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIEQHRAKVKELRQHLWKWGFYTP
DNKHQEEPPFHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006