Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1074 | 1074-30313 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | G73GS | L10I, T12K, I13V, I15V, K20I, E35N, M36I, N37E, R57K, D60E, I62V, L63P, A71T, I72V, P79A |
| >1074-30313| codons 4-99 TLWQRPIVKVKVGGQLIEALLDTGADDTVLENIELPGRWKPKMIGGIGGFIKVKQYEQVP IEICGHKTVSTVLVGATPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, K70R, T215F | D67G, K219Q | Y181C, Y188L, G190A | A98S, K122E, I135T, I142IV, T200E, E203D, F214L, D218E, L228H |
| >1074-30313| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKGSDRWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLLVASDLEIGQHREKIDELRQHLLRWGLFTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |