Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2115 | 2115-30625 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, L210W, T215F | A62V | G190A | A98G, V179D | E44D, S68SG, K101Q, V111I, D121C, K122E, D177E, I178L, T200A, Q207E, H208HY, P243T |
| >2115-30625| codons 38-247 CTELEKDGKISKIGPENPYNTPVFVIKKKDGTKWRKIVDFRELNKRTQDFWEVQLGIPHP GGLQKKKSVTVLDIGDAYFSVPLCEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPELDIYQYMDDLYVASDLEIGQHRAKIEELREYLWRWGFFTP DKKHQKEPPFLWMGYELHPDKWTVQTIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73C | I13V, G16E, K20I, I62V, L63Q, I64V, T74S, T91S |
| >2115-30625| codons 4-99 TLWQRPFVTVKIEGQLIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYDQVQ VEICGHKAICSVLVGPTPVNVIGRNLMSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |