Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1828 | 1828-30529 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54L, I84V, L90M | L10FI, G73T | I13L, E34Q, I62V, L63P, I64V, I66V, P79D, I93L |
| >1828-30529| codons 4-99 TLWQRPIVTLKIGGQLKEALLDTGADDTVLQEMNLPGRWKPKIVGGIGGFLKVRQYDQVP VEVCGHKAITTVLVGDTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | K219H | Y181I | A98G, V108I | S48T, E53D, K173T, Q174K, G196E, I202IV, E203V, L210I, D218E, L228H | K46M |
| >1828-30529| codons 38-247 CTEMEKEGMITKIGPDNPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTILDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRTKNPDIVIIQYMDDLYVGSDLEIEQHRTKVVELRQHLIRWGFTTP EHKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |