Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1827 | 1827-30528 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33F | L10I, L19I, K20R, E35D, M36I, N37D, R41RK, K55KR, I62V, L63P, K70KE, A71V, I72L, I85V, I93L |
| >1827-30528| codons 4-99 TLWQRPIVTIKIGGQIREALLDTGADDTVFEDIDLPGKWKPKLIGGIGGFVRVRQYDQVP IEICGHEVLGTVLVGPTPANIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | K103S, G190A | K238T | K64H, T69NY, K122E, Q174QR, V179I, G196K, I202IV, Q207E, R211RK, L228Q |
| >1827-30528| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIHKKNSYRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKSKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDIIIYQYVDDLYVASDLEIKQHRTKVEELREHLLKWGFFTP DQKHQKEPPFQWMGYELHPDTWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |