Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1658 | 1658-30527 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215F | K219Q | K103N, Y181C, G190A | T39A, E40F, K43E, V60I, K101Q, V111I, V118I, K122E, I135T, Q207QE, H208Y, R211RK, F214L, D218E, L228H, V245E |
| >1658-30527| codons 38-247 CAFLEEEGKISKIGPENPYNTPIFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKNKSVTVLDIGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRTKIEELREYLWKWGLFTP EQKHQKEPPFHWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L89V | I13V, L19Q, K20I, E35D, M36I, N37S, L63P, A71T, I72T, Q92K |
| >1658-30527| codons 4-99 TLWQRPFVTVKIGGQQIEALLDTGADDTVLEDISLPGRWKPKIIGGIGGFVKVRQYDQIP IEICGHKTTGTVLVGPTPVNVIGRNVMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |