Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1061 | 1061-30325 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I47V, I54M, I84V, L90M | L33F | I13V, E34EQ, R41K, L63T, I64L, I66L, A71V, I72T, T74A, V77I, I93L |
| >1061-30325| codons 4-99 TLWQRPLVTVKIGGQLKEALLDTGADDTIFQEMNLPGKWKPKLVGGIGGFMKVRQYDQIT LELCGHKVTGAVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Q151M | A62V, V75VI, F77FL, F116Y | K103N | D123E, I135T, S162N, K173KE, D177E, R211S, F214L |
| >1061-30325| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKDSTKWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYYSVPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQNSMTKILEPFREQNPEIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLSWGLTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |