Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1869 | 1869-30722 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84IV | L24I, L33F, K43T, F53FL, G73GISV | L10I, I13IV, K20R, E35D, M36I, N37E, R57RK, I62IV, L63P, A71AV, T91S |
| >1869-30722| codons 4-99 TLWQRPIVTVKIGGQLREALIDTGADDTVFEDIELPGRWTPKIIGGIGGLVKVKQYDQVP IEICGHKVIVTVLVGPTPANVIGRNLLSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_SA, M184V, T215Y | A62V | V106VA | F227FL | W88C, K122E, I142V, T200A, V245E |
| >1869-30722| codons 38-247 CTELEKEGKISKIGPENPYNTPVFVIKKKDSSKWRKLVDFRELNKRTQDFCEVQLGIPHP AGLKKKKSATVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFYTP DKKHQKEPPLLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |