Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1866 | 1866-30506 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | L10F, L33F, Q58E, G73S | E35D, M36I, N37H, K55KR, I62V, L63P, A71V |
| >1866-30506| codons 5-99 LWQRPFVTIKIGGQLKEALLDTGADDTVFEDIHLPGRWKPKLIGGIGGFVRVREYDQVPI EICGHKVISTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LI, M184V, L210W, T215Y | K219N | K101P, G190GA | E40F, K43E, S68G, K102R, L109I, K122E, E138Q, V179I, T200A, L228HQ |
| >1866-30506| codons 38-247 CTFLEEEGKISKIGPENPYNTPVFAIKKKDGTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLPRKKSVTVIDVGDAYFSVPLDEDFRKYTAFTIPSINNQTPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYVDDLYVASDLEIGQHRAKIEELRQHLWRWGFYTP DNKHQKEPPFQWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |