<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1060 1060-40114 U.S. 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 37

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, V82L, L90M L33F, Q58E, G73S I13V, I15V, K20T, E35D, M36I, I62V, L63P, K70E, A71V, I93L  
>1060-40114| codons 1-99
PQITLWQRPLVTVKVGGQLTEALLDTGADDTVFEDINLPGRWKPKLIGGIGGFIKVREYD
QVPIEICGHEVISTVLVGPTPLNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219N     V35M, K43E, E44A, R83K, K102Q, V118I, K122E, D177E, I178L, I202V, Q207E, A272P, D324E, Q334D, R356K, G359S, V365I, A376S, K390R, Q394L, E399D  
>1060-40114| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELVI
YQYVDDLYVGSDLEIGQHRTKVEELREHLWRWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGDGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDIKQLTEAVQKISTESIVIWGKTPKFRLPILKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006