Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1058 | 1058-30402 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L33LF, G73AT, L89LV | L10I, R41K, K55KR, I62V, L63P, V77VI, V82I, I93L |
| >1058-30402| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGKWKPKIIGGIGGFIRVRQYDQVP IEICGHKAITTVLIGPTPINVIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N | K103N, Y181I | E40F, K43Q, K49R, V60I, V118I, K122E, D123E, I135T, T139V, D177E, V179I, I195L, G196E, T200I, H208Y, R211RK, L228H, V245E |
| >1058-30402| codons 38-247 CTFLEQEGKISRIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSTNNEVPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIIIIQYMDDLYVGSDLELEQHRIKIEELRQYLWKWGFYTP DNKHQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |