Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1057 | 1057-30325 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84V, L90M | L10F, F53L | T12K, I15V, K20R, E21D, M36I, N37D, R41K, K55R, D60E, I62V, L63P, A71V, Q92K |
| >1057-30325| codons 4-99 TLWQRPFVKIKVGGQLRDALLDTGADDTVLEEIDLPGKWKPKMIGGIGGLVRVRQYEQVP IEICGHKVIGTVLVGPTPANVIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | K103N | V108I, P225H | K101Q, K122E, D123E, I135T, D177E, I178M, H208HY |
| >1057-30325| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKNKSVTILDVGDAYFSVPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEMVIYQYMDDLYVGSDLEIGQHRTKIEELRQYLLRWGFFTP DQKHQKEHPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |