Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1056 | 1056-30318 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, I84V | L24I, L33F | L10I, K20R, E35D, M36I, N37DE, L63P, A71V, I93L |
| >1056-30318| codons 4-99 TLWQRPIVTIKIGGQLREALIDTGADDTVFEDIELPGRWKPKLIGGIGGFLKVRQYDQIP IEICGHKVIGTVLVGPTPVNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | Y181C | K49R, V60I, K101KR, V118I, K122E, I135T, S162D, S163SC, E169EA, V179I, I202V, R211K, F214L, L228R |
| >1056-30318| codons 38-247 CTEMEKEGKISRIGPENPYNTPIFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLRKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQDCMTKILAPFRKQNPDIIICQYMDDLYVGSDLEIGQHRTKVEELRQHLLKWGLFTP DQKHQKEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |