Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1055 | 1055-30317 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L33F, Q58E, G73S | L10I, I15V, K20R, E34T, E35D, M36I, N37E, K55R, D60E, I62V, L63P, A71T, I72T, V77I, I85V |
| >1055-30317| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTVFTDIELPGRWKPKIIGGVGGFVRVREYEQVP IEICGHKTTSTVLIGPTPANIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, T215Y | Y181C, Y188L | K43E, E44A, V106I, K122E, I135V, T139K, V189I, G196E, T200A, E203K, L205F, H208Y, L210Y, R211K, K223E, V245K |
| >1055-30317| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSITVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNEKPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLLIGSDLEIEQHRAKIKEFRQYLYKWGFYTP DKKHQEEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |