Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2267 | 2267-30820 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, Y115F, Q151M, M184V, T215FL | V75I, F77L, F116Y, K219Q | Y181C, G190A | V108I | K49R, K101Q, V118I, K122E, S162ST, T165I, Q174R, V179I, G196E, T200A, E203D, F214L, H221Y, L228H |
| >2267-30820| codons 38-247 CTEMEKEGKISRIGPENPYNTPVFAIKKKNSDKWRKLIDLRELNKRTQDFWEVQLGIPHP AGLQKKKSVTILDVGDAFYSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQTSMIKILEPFRKRNPDIIICQYVDDLYVASDLEIEQHRAKIDELRQHLLRWGLLTP DQKYQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | F53L, G73A, L89V | L10I, I13V, L19P, K20V, A22AV, E35G, M36I, D60E, I62V, L63P, I64V, A71I, I72T, V77I, V82I, I85V |
| >2267-30820| codons 4-99 TLWQRPIVTVKIGGQPVEVLLDTGADDTILEGINLPGRWKPKIVGGIGGLMKVRQYEQVP VEICGHKITATVLIGPTPINIVGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |