Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2264 | 2264-30710 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54M, V82A, I84V | L33F | L10I, L24LS, E34Q, N37S, F53FY, I62V, L63P, A71V, P79S, I93L |
| >2264-30710| codons 4-99 TLWQRPIVTIKIGGQLKEALSDTGADDTVFQEMSLPGRWKPKMIVGIGGYMKVRQYDQVP IEICGHKVIGTVLVGSTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219N | T39A, E44D, V118I, K122E, I135T, D177E, V179I, D192DH, I202V, R211K, F214FS, F227FS, V245K |
| >2264-30710| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIIIYQYVDDLYVGSHLEIGQHRTKVEELRQHLWKWGSYTP DNKHQKEPPSLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |