Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2265 | 2265-30710 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, M184V, T215F | D67S, K219E | K103N, Y181C, G190A | A98G, V108I | T69N, R83K, K102KR, L109I, K122E, Q174QR, I202V, H208Y, R211K, D218E, L228H |
| >2265-30710| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKSSNRWRKIVDFRELNKKTQDFWEVQLGIPHP GGLKRNKSVTIIDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDIVICQYVDDLYVASDLEIGQHRTKVEELRQYLLKWGFFTP EEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | I15V, L19I, K20R, E35D, M36I, R57RK, I62V, L63P, H69Q, A71V, V77T |
| >2265-30710| codons 4-99 TLWQRPFVTIKVGGQIREALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVKQYDQVP IEICGQKVITTVLTGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |