Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2035 | 2035-30625 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73C | T4TS, K20I, R41K, Q61H, I62V, L63P, A71AV, I72K, P79N, I85IV, T91TS |
| >2035-30625| codons 4-99 SLWQRPFVTIKIGGQLIEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFVKVRQYDHVP IEICGHKVKCTVLVGNTPVNVVGRNLMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | L100I, K103N | T39A, S68G, K122E, I135T, H208Y, R211K, H221Y, H235HP |
| >2035-30625| codons 38-246 CAELEKEGKISKIGPENPYNTPVFAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTP DKKYQKEPPFLWMGYELPPDKWTVQPIVL |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |