Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2165 | 2165-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219R | K103N | A98G, K238T | T39E, E44D, V60I, I94L, V111I, V118I, K122E, D123N, I135L, E138A, M164L, K166R, V189VI, G196E, T200A, E203D, H208Y, R211K | K173KHNQ |
| >2165-30821| codons 38-247 CEELEKDGKISKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGLPHP GGLKKNKSVTVLDIGDAYFSIPLDENFRKYTAFTIPSLNNATPGIRYQYNVLPQGWKGSP AIFQSSLTRILEPFRQQNPDIVIYQYVDDLYIGSDLEIEQHRAKIDELRQYLWKWGFYTP DRKHQKEPPFLWMGYELHPDTWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | K43KT | L10I, L19LI, K20R, E35D, M36I, N37D, L63P, A71I, I72V, I93M |
| >2165-30821| codons 4-99 TLWQRPIVTIKIGGQIREALLDTGADDTVLEDIDLPGRWTPKMIVGIGGFTKVRQYDQIP IEICGHKIVGTVLVGPTPANIIGRNLLTQMGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |