Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2447 | 2447-30820 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| F53FL | L10LI, K20KR, E35ED, M36I, N37D, I62V, L63P, A71T, I72V, I93L |
| >2447-30820| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGLIKVRQYDQVP IEICGHKTVGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184I, L210W, T215Y | K219R | K103NS | V108VI | T39E, E44D, V60I, V90I, V118I, T139R, S162A, Q174K, N175Y, D177E, I178M, V179VI, G196E, K201R, Q207E, R211K, H221HY |
| >2447-30820| codons 38-247 CEELEKDGKISKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKSKSVTILDVGDAYFSIPLDKDFRKYTAFTIPSINNERPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFRKKYPEMIIYQYIDDLYVGSDLEIEQHRTRIEELREHLWKWGFYTP DRKYQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |