Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2164 | 2164-30724 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I50V, V82A | L10F, L33F | T12N, M36L, N37D, L63P, A71V, Q92K |
| >2164-30724| codons 4-99 TLWQRPFVNIKIGGQLKEALLDTGADDTIFEELDLPGRWKPKIVGGVGGFIKVRQYDQIP IEICGHKVIGTVLVGPTPANIIGRNLLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219R | E44D, V118I, K122E, I135V, S162C, D177E, I195IT, G196E, E204G, R211K |
| >2164-30724| codons 38-246 CTELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLETEQHRTKIEGLRQHLWKWGFYTP DRKHQKEPPFLWMGYELHPDKWTVQPIVL |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |