Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1018 | 1018-30520 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, L33F, K43IT, G73C | L10I, I15V, L19LI, M36L, N37S, L38W, P39PS, R41RK, I62V, L63P, A71V |
| >1018-30520| codons 4-99 TLWQRPIVTIKVGGQIKEALIDTGADDTVFEELSWSGKWTPKLIGGIGGFVKVRQYDQVP IEICGHKVICTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | K103N | A98G, V108I | K43KN, E44D, V118I, K122E, S162C, E169D, N175H, V189I, T200A, K201M, E203D, H208Y, R211K, H221Y |
| >1018-30520| codons 38-247 CTELENDGKISKIGPENPYNTPVFAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILDPFRKQHPDIVIYQYVDDLYIGSDLEIGQHRAMIDELRQYLWKWGFYTP DKKYQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |