<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2376 2376-30821 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70KR, L74I, T215F K219Q Y181YC, G190A V179D T39A, K64H, T69N, K103R, V111VI, K122E, I142V, I178M, V189I, T200A, E203A, Q207E, H208Y, R211K, L228H  
>2376-30821| codons 38-247
CAELEKEGKISKIGPENPYNTPVFAIHKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHP
AGLKKRKSVTVLDIGDAYFSVPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDMDICQYMDDLYIASDLEIGQHRAKIAELREYLLKWGFFTP
DQKHQKEPPFHWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50L, I54V, V82L, L90M L33F, G73C, T74P L10I, V11L, I13V, G16A, K20R, E35D, M36I, N37D, R41K, I62V, L63P, A71V, I93L L89A
>2376-30821| codons 4-99
TLWQRPILTVKIAGQLREALLDTGADDTVFEDIDLPGKWKPKIIGGLGGFVKVRQYDQVP
IEICGHKVICPVLVGPTPLNIIGRNAMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006