Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2376 | 2376-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50L, I54V, V82L, L90M | L33F, G73C, T74P | L10I, V11L, I13V, G16A, K20R, E35D, M36I, N37D, R41K, I62V, L63P, A71V, I93L | L89A |
| >2376-30821| codons 4-99 TLWQRPILTVKIAGQLREALLDTGADDTVFEDIDLPGKWKPKIIGGLGGFVKVRQYDQVP IEICGHKVICPVLVGPTPLNIIGRNAMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74I, T215F | K219Q | Y181YC, G190A | V179D | T39A, K64H, T69N, K103R, V111VI, K122E, I142V, I178M, V189I, T200A, E203A, Q207E, H208Y, R211K, L228H |
| >2376-30821| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIHKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKRKSVTVLDIGDAYFSVPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMDICQYMDDLYIASDLEIGQHRAKIAELREYLLKWGFFTP DQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |