Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2375 | 2375-30813 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | L100I, K103N | T39E, V60I, V118I, K122E, I135T, S162SN, N175H, I178V, T200K, K201M, Q207E, H208Y, R211K, K223T |
| >2375-30813| codons 38-247 CEELEKEGKISKIGPENPYNTPIFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKQHPDVVIYQYVDDLYVGSDLEIGQHRKMIEELREYLWKWGFYTP DKKHQTEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | V11I, G73S | L10I, T12P, I13V, K14R, I15V, K20I, E35EG, M36I, R41K, D60E, I62V, L63P, A71V, I72M |
| >2375-30813| codons 4-99 TLWQRPIIPVRVGGQLIEALLDTGADDTVLEGINLPGKWKPKIIGGIGGFVKVRQYEQVP IEICGHKVMSTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |