<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2374 2374-30812 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46MI, I47IV, I54IV, V82A, L90M   L10V, T12P, L19S, K20R, E35D, M36I, N37S, R57RK, L63P, H69HQ, A71V, I93ILM  
>2374-30812| codons 4-99
TLWQRPVVPIKIGGQSREALLDTGADDTILEDISLPGRWKPKIVGGIGGFVKVKQYDQIP
IEICGQKVIGTVLVGPTPANIIGRNLMTQMGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184MV, L210W, T215Y K219N K103NS, Y181YC V108I K43Q, E44D, A98S, V118I, K122E, I135V, K173A, Q174K, D177DG, T200A, E203D, Q207E, H208Y, R211K, H221Y D113N
>2374-30812| codons 38-247
CTELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP
SGLKKSKSVTILDVGNAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRAKNPGIVICQYVDDLYVGSDLEIGQHRAKIDELREYLWKWGFYTP
DNKYQKEPPFLWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006