Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2373 | 2373-30804 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A | L10F, L33F, K43T | I13V, K20R, M36I, N37S, L63P, A71V, I72V |
| >2373-30804| codons 4-99 TLWQRPFVTVKIGGQLREALLDTGADDTIFEEISLPGRWTPKIVGGIGGFMKVRQYDQIP IEICGHKVVGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, K70R, L74V, M184V, T215F | D67G, K219Q | S68G, K103Q, V118I, D123E, I142V, S162D, P170S, T200I, F214L |
| >2373-30804| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKGGDRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKQKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQDSMTKILESFRKQNPDIVIYQYVDDLYVGSDLEIGQHRIKIEELRQHLLRWGLFTP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |