Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2372 | 2372-30730 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K65R, Q151M, M184V | A62V, V75I, F77L, F116Y | G190S | T58N, S68K, D123E, I142T, S162ST, S163SC, E169D, I202IV, R211K, V245M |
| >2372-30730| codons 38-247 CTELEKEGKISKIGPENPYNNPVFVIKRKDKTKWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYYSVPLDKEFRKYTAFTIPSINNETPGTRYQYNVLPMGWKGSP AIFQTCMTKILDPFRKQNPDIVIYQYVDDLYVSSDLEIGQHRTKVEELRQHLLKWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54L, I84V, L90M | L10F, L33F, Q58E, G73S, L89V | I13V, I15V, K20R, E34Q, E35D, M36I, N37D, I62V, L63P, I66F, I72L, V77VI |
| >2372-30730| codons 4-99 TLWQRPFVTVKVGGQLREALLDTGADDTIFQDIDLPGRWKPKMVGGIGGFLKVREYDQVP IEFCGHKALSTVLIGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |