Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2371 | 2371-30730 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75M, M184V, T215F | F77L, K219Q | A98G | T39TA, K43KN, V118VI, D121H, K122E, I135T, K166Q, D177E, V179I, G196E, Q207H, R211K, D218E, L228K, V245E |
| >2371-30730| codons 38-247 CAELENEGKISKIGPENPYNTPVFAIKKKNSTKWRKIMDLRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSIPLHEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTQILEPFRKQNPEIIIYQYVDDLYVGSDLEIEQHRTKIEELRHHLLKWGFFTP EQKHQKEPPFKWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54S, V82A, L90M | L33F, Q58E | L5F, L10I, I13V, E34Q, N37NS, D60E, I62V, L63P, H69R, A71L, V77I, I93L |
| >2371-30730| codons 4-99 TFWQRPIVTVKIGGQLKEALLDTGADDTVFQEMSLPGRWKPKMIVGIGGFSKVREYEQVP IEICGRKLIGTVLIGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |