<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2371 2371-30730 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54S, V82A, L90M L33F, Q58E L5F, L10I, I13V, E34Q, N37NS, D60E, I62V, L63P, H69R, A71L, V77I, I93L  
>2371-30730| codons 4-99
TFWQRPIVTVKIGGQLKEALLDTGADDTVFQEMSLPGRWKPKMIVGIGGFSKVREYEQVP
IEICGRKLIGTVLIGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, V75M, M184V, T215F F77L, K219Q   A98G T39TA, K43KN, V118VI, D121H, K122E, I135T, K166Q, D177E, V179I, G196E, Q207H, R211K, D218E, L228K, V245E  
>2371-30730| codons 38-247
CAELENEGKISKIGPENPYNTPVFAIKKKNSTKWRKIMDLRELNKRTQDFWEVQLGIPHP
GGLKKKKSVTVLDVGDAYFSIPLHEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTQILEPFRKQNPEIIIYQYVDDLYVGSDLEIEQHRTKIEELRHHLLKWGFFTP
EQKHQKEPPFKWMGYELHPDKWTVQPIELP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006